Colonization-Induced Host-Gut Microbial Metabolic Interaction - 0 views
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he gut microbiota enhances the host’s metabolic capacity for processing nutrients and drugs and modulate the activities of multiple pathways in a variety of organ systems.
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Acquisition of the gut microbiota was associated with rapid increase in body weight (4%) over the first 5 days of colonization
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The colonization process stimulated glycogenesis in the liver prior to triggering increases in hepatic triglyceride synthesis
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Expression and activity of major drug-metabolizing enzymes (Cyp3a11 and Cyp2c29) were also significantly stimulated
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The gut microbiota (GM) exhibits a relatively low level of diversity compared to those of most soil ecosystems and in humans it is comprised of usually no more than nine phyla of microorganisms, of which only two are dominant: the Firmicutes and the Bacteroidetes
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colonization of a germfree gut was rapid and remarkably stable, establishing within only a week after first exposure
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a study conducted on germfree rats by Nicholls et al. showed that 3 weeks were necessary to obtain a stabilization and “normalization”
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the microbiota status affects the systemic metabolism of the host, modulating the metabolic fingerprint of topographically remote organs such as the liver and the kidney
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Gut colonization induces a rapid weight gain associated with stimulation of hepatic glycogenesis and triglyceride synthesis